Rascal from South, affected (5)
I believe the answer is:
scamp
'rascal' is the definition.
('scamp' can be a synonym of 'rascal')
'south affected' is the wordplay.
'south' becomes 's' ('S' can be a synonym of 'south').
'affected' becomes 'camp' (I've seen this before).
's'+'camp'='SCAMP'
'from' is the link.
(Other definitions for scamp that I've seen before include "pickle" , "Little Devil" , "A young rascal misbehaving in camps" , "Tearaway" , "little monkey" .)