Rash protest mostly subdued without resistance rising (10)
I believe the answer is:
dermatitis
'rash' is the definition.
(thesaurus)
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for dermatitis that I've seen before include "Skin trouble" , "Met diarist (anag.)" , "Skin inflammation" , "Skin ailment" .)