Rather sour tonic tends to go off (10)
I believe the answer is:
discontent
'rather sour' is the definition.
'tonic tends to go off' is the wordplay.
'to go off' indicates anagramming the letters.
'tonic'+'tends'='tonictends'
'tonictends' with letters rearranged gives 'DISCONTENT'.
(Other definitions for discontent that I've seen before include "Lack of satisfaction" , "Dissatisfaction" , "blighted Gloucester's winter" , "Bad feelings" , "Now is the winter of our - (Rich.III)" .)