Realm in which no maid is in distress (6)
I believe the answer is:
domain
'realm' is the definition.
(synonyms)
'no maid is in distress' is the wordplay.
'is in distress' is an anagram indicator.
'no'+'maid'='nomaid'
'nomaid' anagrammed gives 'DOMAIN'.
'in which' acts as a link.
(Other definitions for domain that I've seen before include "Special region, area of expertise" , "Field of thought or activity" , "estate" , "Realm or range of influence" , "Range of influence or field of activity" .)