Refrain of concern across the globe (7)
I believe the answer is:
forbear
'refrain' is the definition.
(I know that forbear is a more specific form of refrain)
'concern across the globe' is the wordplay.
'concern' becomes 'fear' (synonyms).
'across' is an insertion indicator.
'the globe' becomes 'orb' ('orb' can be a synonym of 'globe').
'fear' enclosing 'orb' is 'FORBEAR'.
'of' acts as a link.
(Other definitions for forbear that I've seen before include "Refrain from doing something" , "Abstain" , "Be patient" , "Hold back" .)