Refuse from almost everybody (5)
I believe the answer is:
offal
'refuse' is the definition.
(I've seen this before)
'from almost everybody' is the wordplay.
'from' becomes 'off' (eg someone might be from or 'off' a TV show).
'almost' means to remove the last letter (almost the whole word is kept).
'everybody' becomes 'all' (all people).
'all' with its last letter removed is 'al'.
'off'+'al'='OFFAL'
(Other definitions for offal that I've seen before include "Edible (or inedible!) animal organs" , "Animal entrails and internal organs as rubbish" , "Less valuable edible parts of animal" , "Edible heart, liver and tongue, for instance" , "Entrails used as food" .)