Regard eccentric up tree (6)
I believe the answer is:
repute
'regard' is the definition.
(I have seen 'High regard ' mean 'repute' so perhaps 'regard' could also mean 'repute')
'eccentric up tree' is the wordplay.
'eccentric' indicates anagramming the letters.
'up'+'tree'='uptree'
'uptree' anagrammed gives 'REPUTE'.
(Other definitions for repute that I've seen before include "Fame, renown" , "State of high regard" , "Distinction" , "credit" , "Generally held opinion" .)