Regardless of (2,6)
'regardless of' is the definition.
(I've seen this before)
This is the entire clue.
(Other definitions for no matter that I've seen before include "It doesn't make any difference" , "Regardless of" , "Irrespective of" , "It's not important - what a torment" , "Forget it!" .)
'regardless of' is the definition.
(synonyms)
This is all the clue.
(Other definitions for despite that I've seen before include "In the face" , "Undeterred" , "Regardless of, in defiance of" , "Notwithstanding" , "Without being affected by; contempt" .)