Region sadly showing neglect (6)
I believe the answer is:
ignore
'neglect' is the definition.
('ignore' can be a synonym of 'neglect')
'region sadly' is the wordplay.
'sadly' indicates an anagram.
'region' is an anagram of 'IGNORE'.
'showing' acts as a link.
(Other definitions for ignore that I've seen before include "Cut head off" , "Refuse to notice or acknowledge" , "Pay no heed to" , "Pass over" , "Neglect" .)