Regretted about home being destroyed (6)
I believe the answer is:
ruined
'being destroyed' is the definition.
(similar in meaning)
'regretted about home' is the wordplay.
'regretted' becomes 'rued' ('rue' can be a synonym of 'regret').
'about' means one lot of letters goes inside another.
'home' becomes 'in' ('he's home' can mean 'he's in').
'rued' enclosing 'in' is 'RUINED'.
(Other definitions for ruined that I've seen before include "Wrecked" , "Bankrup - destroyed" , "Broke" , "Done for" , "Physically destroyed or financially impoverished" .)