Religion is assigned unlimited blame (5)
I believe the answer is:
islam
'religion' is the definition.
(Islam is an example)
'is assigned unlimited blame' is the wordplay.
'assigned' means one lot of letters go next to another.
'unlimited' says to take the centre (discard the edges or 'limits' of the word).
The middle of 'blame' is 'lam'.
'is'+'lam'='ISLAM'
(Other definitions for islam that I've seen before include "Mails to Muslim religion" , "Religion of the Koran" , "Mohammed's religion" , "Major world religion" , "Adherents of a religion" .)