Remain in Mulholland Drive? (4)
I believe the answer is:
last
'remain' is the definition.
(thesaurus)
I cannot understand how the rest of the clue works.
(Other definitions for last that I've seen before include "Least likely" , "model of repair" , "Cargo to stay fresh" , "Endure - this clue is!" , "Ultimate - endure" .)