Remark about man having 500 in order (11)
I believe the answer is:
commandment
'order' is the definition.
(thesaurus)
'remark about man having 500' is the wordplay.
'remark' becomes 'comment' (synonyms).
'about' is an insertion indicator.
'having' says to put letters next to each other.
'e00' becomes 'D' (Roman numeral for e00).
'man'+'d'='mand'
'comment' going around 'mand' is 'COMMANDMENT'.
'in' acts as a link.
(Other definitions for commandment that I've seen before include "Order (one of ten)" , "Divine rule" .)