Remove from F1 (6)
I believe the answer is:
efface
'remove' is the definition.
(I've seen this before)
'from f1' is the wordplay.
I cannot really understand how this works, but
'from' could be 'e' (I've seen this in other clues) and 'e' is found in the answer.
'f1' could be 'f' and 'f' is found within the answer.
The remaining letters 'face' is a valid word which might be clued in a way I don't understand.
This explanation may well be incorrect...
(Other definitions for efface that I've seen before include "Do away with" , "Rub out entirely, obliterate" , "Remove all traces of" , "Remove all trace of" , "The selling of goods in large quantities" .)