Removes contents of bottle (4)
I believe the answer is:
guts
This clue is a double definition.
'removes contents' is the first definition.
'bottle' is the second definition.
(I've seen this before)
'of' acts as a link.
(Other definitions for guts that I've seen before include "Courage, determination" , "stamina!" , "Intestines; bravery" , "Intestines - courage" , "Pluck -- intestines" .)