Renounce, have nothing to do with (4,2)
I believe the answer is:
pass up
This clue is a double definition.
'renounce' is the first definition.
(thesaurus)
'have nothing to do with' is the second definition.
(I've seen this before)
(Other definitions for pass up that I've seen before include "forego" , "Neglect (an opportunity)" , "Showing neglect" , "Refuse - reject" , "Refrain from taking an opportunity" .)