Repeatedly manhandle fruit (6)
I believe the answer is:
pawpaw
'fruit' is the definition.
(pawpaw is a kind of fruit)
'repeatedly manhandle' is the wordplay.
'repeatedly' shows that letters should be duplicated.
'manhandle' becomes 'paw' (I've seen this before).
'paw' duplicated is 'PAWPAW'.
(Other definitions for pawpaw that I've seen before include "Papaya" , "Custard apple tree" , "Fruit" , "foul once" .)