Reply from lesbians we respect (6)
I believe the answer is:
answer
'reply' is the definition.
('answer' can be a synonym of 'reply')
'from lesbians we respect' is the wordplay.
'from' says the answer is hidden in the clue.
'ANSWER' can be found hidden inside 'lesbians we respect'.
(Other definitions for answer that I've seen before include "Reply or 8 across" , "Write back" , "'A soft . . . . . . turneth away wrath'" , "Respond" , "See 9" .)