Report a loner missing from New Orleans (4)
I believe the answer is:
news
'report' is the definition.
(synonyms)
I don't understand the rest of the clue.
Can you help me to learn more?
(Other definitions for news that I've seen before include "Sewn (anag.)" , "This is compiled for one" , "Fresh tidings" , "Four points" , "Noteworthy information" .)