Report supporting female's affair (7)
I believe the answer is:
shebang
'affair' is the definition.
('shebang' can informally refer to a matter or situ)
'report supporting female's' is the wordplay.
'report' becomes 'bang' (I've seen this before).
'supporting' means one lot of letters go next to another (in a down clue, some letters go below others).
'female' becomes 'she' (I've seen this before).
'bang' after 'she' is 'SHEBANG'.
(Other definitions for shebang that I've seen before include "The whole ___ (entirely)" , "Lot" , "The entire system" , "affair in America" , "The whole thing?" .)