Reputable home for prostitute? (6)
I believe the answer is:
honest
'reputable' is the definition.
(thesaurus)
'home for prostitute?' is the wordplay.
'home' becomes 'nest' (I've seen this before).
'for' is a charade indicator (letters next to each other) (I've seen this in other clues).
'prostitute?' becomes 'ho' (I've seen this in other clues).
'nest' after 'ho' is 'HONEST'.
(Other definitions for honest that I've seen before include "'Fair-dealing, upright (6)'" , "Objective mediator" , "Free of deceit, truthful by nature" , "Upright and straightforward" , "Free from guile" .)