Require extremely large part of gramophone (6)
I believe the answer is:
needle
'part of gramophone' is the definition.
(I've seen this before)
'require extremely large' is the wordplay.
'require' becomes 'need' (synonyms).
'extremely' says to hollow out the word (remove centre letters) (only the extremes of the word are used).
'large' with its centre taken out is 'le'.
'need'+'le'='NEEDLE'
(Other definitions for needle that I've seen before include "Irritate; pine leaf" , "pinnacle of rock" , "Annoy - syringe" , "Unnecessary" , "Knitting rod" .)