Resident at home with wife (6)
I believe the answer is:
inmate
'resident' is the definition.
(inmate is a kind of resident)
'home with wife' is the wordplay.
'home' becomes 'in' ('he's home' can mean 'he's in').
'with' is a charade indicator (letters next to each other).
'wife' becomes 'mate'.
'in'+'mate'='INMATE'
'at' acts as a link.
(Other definitions for inmate that I've seen before include "Someone confined, eg to hospital or prison" , "Person confined to institution" , "One held in prison" , "eg Prisoner" , "Lag" .)