Resign on account of work (5)
I believe the answer is:
forgo
'resign' is the definition.
(thesaurus)
'account of work' is the wordplay.
'account of' becomes 'for' (I've seen this in other clues).
'work' becomes 'go' (synonyms).
'for'+'go'='FORGO'
'on' is the link.
(Other definitions for forgo that I've seen before include "Do without (something desirable)" , "Sacrifice" , "Abjure" , "Live without" , "Relinquish, give up" .)