Resort in South America's quiet (3)
I believe the answer is:
spa
'resort' is the definition.
(spa is a kind of resort)
'in south america's quiet' is the wordplay.
'in' means one lot of letters goes inside another.
'south' becomes 's' (synonyms).
'america' becomes 'a' (common abbreviation - e.g. in organisation names).
'quiet' becomes 'p' (music symbol for 'piano').
's'+'a'='sa'
'sa' placed around 'p' is 'SPA'.
(Other definitions for spa that I've seen before include "here for the good of his health?" , "Bath, possibly" , "Boston" , "health centre" , "hydro" .)