Restless natives, most proud! (7)
I believe the answer is:
vainest
'most proud' is the definition.
('vain' can be similar in meaning to 'proud')
'restless natives' is the wordplay.
'restless' indicates an anagram (letters not resting).
'natives' anagrammed gives 'VAINEST'.
(Other definitions for vainest that I've seen before include "Arrogant in the extreme" , "with lowest hopes" , "Most proud" , "Most fond of one's own looks" , "least humble" .)