Reversal
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">reversal</span>' is the definition.<br/ ><span class="explanation-format__explanation">(synonyms)</span><br/ ><br/ >This is all the clue.<br/ ></span>
(Other definitions for setback that I've seen before include "Check" , "Reversal of fortune" , "Problem" , "disappointment" , "Hitch" .)
(Other definitions for role that I've seen before include "Part, portrayal" , "Acting part" , "Part (in drama)" , "Part played (in life?)" , "Duty" .)
(Another definition for uturn that I've seen is " policy reversal".)