Rid oneself of many a desire (5)
I believe the answer is:
ditch
'rid' is the definition.
(thesaurus)
'many a desire' is the wordplay.
'many' becomes 'D' (Roman numeral for 500).
'a desire' becomes 'itch' (itch is a kind of desire).
'd'+'itch'='DITCH'
'oneself of' is the link.
This may not be right. Some or all of it may belong to another bit of the clue.
Can you help me to learn more?
(Other definitions for ditch that I've seen before include "give up" , "Furrow, trench" , "Boundary trench" , "Throw away (sl.)" , "Narrow channel" .)