Ride out in direction that's most strange (8)
I believe the answer is:
weirdest
'most strange' is the definition.
('weird' can be a synonym of 'strange')
'ride out in direction' is the wordplay.
'out' indicates an anagram (out can mean wrong or inaccurate).
'in' means one lot of letters goes inside another.
'direction' becomes 'west' (compass direction).
'ride' is an anagram of 'irde'.
'irde' put inside 'west' is 'WEIRDEST'.
'that's' acts as a link.
(Other definitions for weirdest that I've seen before include "Most unearthly" , "Most strikingly odd" , "Most uncanny!" , "Most bizarre" .)