Rise and stagger round bathroom initially (5)
I believe the answer is:
rebel
'rise' is the definition.
(I know that rise can be written as rebel)
'stagger round bathroom initially' is the wordplay.
'stagger' becomes 'reel' (both can mean to move around without balance).
'round' means one lot of letters goes inside another.
'initially' indicates taking the first letters.
The first letter of 'bathroom' is 'b'.
'reel' enclosing 'b' is 'REBEL'.
'and' is the link.
(Other definitions for rebel that I've seen before include "Show dissent" , "Insurgent, mutineer" , "Refuse orders" , "One rising in opposition" , "Oppose authority" .)