Risk making many rage (6)
I believe the answer is:
danger
'risk' is the definition.
('danger' can be a synonym of 'risk')
'many rage' is the wordplay.
'many' becomes 'd' (**).
'rage' becomes 'anger' (I've seen this before).
'd'+'anger'='DANGER'
'making' is the link.
(Other definitions for danger that I've seen before include "Peril, hazard" , "Peril, exposure to harm" , "Undesirable possibility" , "Ranged about in some peril" , "Menace" .)