River bend with profundity (6)
I believe the answer is:
deeply
'with profundity' is the definition.
(I've seen this before)
'river bend' is the wordplay.
'river' becomes 'Dee' (River Dee).
'bend' becomes 'ply' (I can't justify this - if you can you should give a lot more credence to this answer).
'dee'+'ply'='DEEPLY'
Can you help me to learn more?
(Other definitions for deeply that I've seen before include "In a profound way" , "Thoroughly" , "Profoundly" , "With profundity" , "With intense feeling" .)