River runs away from country houses (6)
I believe the answer is:
ganges
'river' is the definition.
(Ganges is an example)
'runs away from country houses' is the wordplay.
'runs' becomes 'r' (cricket abbreviation).
'away from' indicates named letters should be taken away.
'country houses' becomes 'granges' (country house with a farm).
'granges' with 'r' removed is 'GANGES'.
(Other definitions for ganges that I've seen before include "Sacred Hindu river in India" , "River flowing into the Bay of Bengal" , "Holy water" , "Asian flower" , "Great river of India" .)