Rob’s upset over Ken being ruined! (6)
I believe the answer is:
broken
'being ruined' is the definition.
(thesaurus)
'rob's upset over ken' is the wordplay.
'upset' is an anagram indicator.
'over' says to put letters next to each other.
'rob' is an anagram of 'bro'.
'bro'+'ken'='BROKEN'
(Other definitions for broken that I've seen before include "Interrupted; crushed" , "out of order" , "Fractured, damaged" , "Smashed or tamed" , "Bust" .)