Roll dope, have a little smoke (5)
I believe the answer is:
twist
'roll' is the definition.
(thesaurus)
'dope have a little smoke' is the wordplay.
'dope' becomes 'twit' (both can mean a stupid person).
'have' means one lot of letters goes inside another.
'a little' says to take the initial letters.
The first letter of 'smoke' is 's'.
'twit' placed around 's' is 'TWIST'.
(Other definitions for twist that I've seen before include "Energetic dance for twits" , "One who asked for more" , "Turn; cheat" , "Strong thread" , "Who could ask for more!" .)