Romeo in state of excitement takes both right off - the ladies love him (10)
I believe the answer is:
heartthrob
'ladies love him' is the definition.
The answer is a person as well as being a singular noun. This is suggested by the definition.
'romeo in state of excitement takes both right off' is the wordplay.
'romeo in state of excitement takes' becomes 'heart' (I can't justify this - if you can you should believe this answer much more).
'right' becomes 'r' (common abbreviation).
'off' indicates anagramming the letters.
'both'+'r'='bothr'
'bothr' with letters rearranged gives 'throb'.
'heart'+'throb'='HEARTTHROB'
'the' acts as a link.
Can you help me to learn more?
(Other definitions for heartthrob that I've seen before include "Beat" , "Romantic and good-looking male celebrity" , "idol" , "Object of fascination" .)