Roots out drug issues involving cocaine (10)
I believe the answer is:
eradicates
'roots out' is the definition.
'drug issues involving cocaine' is the wordplay.
'drug' becomes 'e' (e is another name for ecstasy).
'issues' becomes 'radiates'.
'involving' is an insertion indicator.
'cocaine' becomes 'c' ('C' can be a synonym of 'cocaine').
'radiates' placed around 'c' is 'radicates'.
'e'+'radicates'='ERADICATES'
(Another definition for eradicates that I've seen is " Kills".)
I've seen this clue in The Independent.
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