Rose, shuffling around in Piccadilly Circus (4)
'in piccadilly circus' is the definition.
Although both the answer and definition are singular nouns, I can't see how one could define the other.
'rose shuffling' is the wordplay.
'shuffling' indicates anagramming the letters.
'rose' with letters rearranged gives 'EROS'.
'around' acts as a link.
Can you help me to learn more?
(Other definitions for eros that I've seen before include "Piccadilly 14 ac statue", "very centre of London?", "Form of love", "Name given to statue", "Cupid, to the Greeks".)