Rough guards let to wander, travel-worn (3-6)
I believe the answer is:
jet-lagged
'travel-worn' is the definition.
Both the definition and answer are adjectives.
Perhaps you can see an association between them that I can't see?
'rough guards let to wander' is the wordplay.
'rough' becomes 'jagged' (similar in meaning).
'guards' means one lot of letters goes inside another (inserted letters are guarded).
'to wander' indicates anagramming the letters.
'let' with letters rearranged gives 'etl'.
'jagged' enclosing 'etl' is 'JET-LAGGED'.
Can you help me to learn more?
(Other definitions for jet-lagged that I've seen before include "Suffering from high-speed, long-distance air travel" , "Tired from long-distance air travel" , "Suffering from fatigue due to air travel" .)