Rough region to disregard intentionally (6)
I believe the answer is:
ignore
'disregard intentionally' is the definition.
(I've seen this before)
'rough region' is the wordplay.
'rough' indicates anagramming the letters (a rough or broken ordering of the letters).
'region' is an anagram of 'IGNORE'.
'to' acts as a link.
(Other definitions for ignore that I've seen before include "Brush off" , "Intentionally disregard" , "Cut head off" , "Refuse to notice or acknowledge" , "Disregard - cut" .)