Roughly punishes with pain ignoring one's misery (11)
I believe the answer is:
unhappiness
'misery' is the definition.
(thesaurus)
'roughly punishes with pain ignoring one's' is the wordplay.
'roughly' is an anagram indicator.
'with' is a charade indicator (letters next to each other).
'ignoring' is a deletion indicator.
'one' becomes 'i' (Roman numeral).
'punishes' put after 'pain' is 'painpunishes'.
'painpunishes' with 'i' taken away is 'panpunishes'.
'panpunishes' is an anagram of 'UNHAPPINESS'.
(Other definitions for unhappiness that I've seen before include "misfortune" , "Misery" .)