Rubber, strangely rare round south-east (6)
I believe the answer is:
eraser
'rubber' is the definition.
(rubber can mean an eraser)
'strangely rare round south-east' is the wordplay.
'strangely' is an anagram indicator.
'round' indicates putting letters inside.
'south east' becomes 'SE' (abbreviation).
'rare' with letters rearranged gives 'erar'.
'erar' enclosing 'se' is 'ERASER'.
(Other definitions for eraser that I've seen before include "Implement to rub out" , "Rubbing-out device" , "Rubber for removing marks" , "Stationery item" , "India rubber" .)