Rudeness: unfortunate recipient, men! (12)
I believe the answer is:
impertinence
'rudeness' is the definition.
(impertinence is a kind of rudeness)
'unfortunate recipient men' is the wordplay.
'unfortunate' is an anagram indicator.
'recipient'+'men'='recipientmen'
'recipientmen' anagrammed gives 'IMPERTINENCE'.
(Other definitions for impertinence that I've seen before include "Rudeness" , "Nerve" , "Insolence" , "Lack of respect" , "cheek or lip" .)