Rum making saint wander (7)
I believe the answer is:
strange
'rum' is the definition.
(synonyms)
'saint wander' is the wordplay.
'saint' becomes 'st' (abbreviation).
'wander' becomes 'range' (synonyms).
'st'+'range'='STRANGE'
'making' acts as a link.
(Other definitions for strange that I've seen before include "Extraordinary" , "Bizarre" , "Irregular" , "Odd, not familiar" , "Singular" .)