Run from large snake (6)
I believe the answer is:
ladder
'run' is the definition.
(both can mean a rip in tights)
'large snake' is the wordplay.
'large' becomes 'L' (eg in clothes sizes).
'snake' becomes 'adder' (type of snake).
'l'+'adder'='LADDER'
'from' is the link.
(Other definitions for ladder that I've seen before include "Climbing structure" , "Scaling device" , "Companionway" , "Run in stockings" , "Climbing frame; damage tights" .)