Run from student in charge (4)
I believe the answer is:
flee
'run from' is the definition.
(I've seen this before)
'student in charge' is the wordplay.
'student' becomes 'l' (as in L-plates for learner drivers).
'in' is an insertion indicator.
'charge' becomes 'fee' (fee is a kind of charge**).
'l' inserted inside 'fee' is 'FLEE'.
(Other definitions for flee that I've seen before include "Run quickly away" , "head for the hills" , "Do a runner" , "Cut and run" , "Take flight" .)