Run ___ (go off the rails) (4)
I believe the answer is:
amok
(Other definitions for amok that I've seen before include "(Run) in murderous frenzy" , "Frenziedly" , "Running wild" , "Berserk" , "'Wildly, without self-control (4)'" .)
I believe the answer is:
amok
(Other definitions for amok that I've seen before include "(Run) in murderous frenzy" , "Frenziedly" , "Running wild" , "Berserk" , "'Wildly, without self-control (4)'" .)