Crossword Genius

Run into hot ring? It may damage tissue (10)

Ross

I believe the answer is:

infarction

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'it may damage tissue' is the definition.
The definition suggests a singular noun which matches the answer.

'run into hot ring?' is the wordplay.
'run' becomes 'infarct' (I can't explain this - if you can you should believe this answer much more).
'into' is an insertion indicator.
'hot' becomes 'in' (both can mean fashionable).
'ring?' becomes 'o' (letter resembling a ring).
'in' enclosing 'o' is 'ion'.
'infarct'+'ion'='INFARCTION'

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I've seen this clue in The Irish Times.
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