Run off at outset of disturbance (6)
I believe the answer is:
unrest
'disturbance' is the definition.
(I've seen this before)
'run off at outset' is the wordplay.
'off' is an anagram indicator.
'at outset' becomes 'est' (I am not sure about this - if you are sure you should believe this answer much more).
'run' anagrammed gives 'unr'.
'unr'+'est'='UNREST'
'of' acts as a link.
Can you help me to learn more?
(Other definitions for unrest that I've seen before include "'Disturbance, agitation (6)'" , "Disorder" , "Uneasiness; turmoil" , "Turmoil, disquiet" , "Feeling of anxiety or turmoil" .)