Running round most of valley, seizing time without ramblers? (9)
I believe the answer is:
untrodden
'without ramblers?' is the definition.
(as in a path which ramblers have not trod on)
'running round most of valley seizing time' is the wordplay.
'running' indicates an anagram.
'most of' means to remove the last letter.
'valley' becomes 'dene' (I've seen this before).
'seizing' indicates putting letters inside.
'time' becomes 't'.
'dene' with its final letter taken off is 'den'.
'round' with letters rearranged gives '[round]'.
'[round]'+'den'='unrodden'
'unrodden' placed around 't' is 'UNTRODDEN'.
(Other definitions for untrodden that I've seen before include "Unfrequented" , "Not having been walked on" , "Description of virgin territory" .)